Indian Journal of Public Health Research & Development

A. Trishala ¹, T. Lakshmi ², S. Rajeshkumar ², Deepa Gurunathan ³, R. V. Geetha ⁴, Anitha Roy ²

Affiliations
1 Undergraduate Student, Department of Pharmacology, Saveetha Dental College, SIMATS, Saveetha University Chennai, Tamil Nadu, IN
2 Associate Professor, Department of Pharmacology, Saveetha Dental College, SIMATS, Saveetha University Chennai, Tamil Nadu, IN
3 Professor, Department of Pedodontics & Preventive Dentistry, Saveetha Dental College, SIMATS, Saveetha University Chennai, Tamilnadu, IN
4 Associate Professor, Department of Microbiology, Saveetha Dental College, SIMATS, Saveetha University Chennai, Tamilnadu, IN

Abstract

Introduction: Acacia catechu has a great importance due to its medicinal properties. It is a historical plant; widely used in traditional medicine especially in Asia. The bark of this plant is strong antioxidant, astringent, anti-inflammatory, anti-bacterial and antifungal in nature. It is used as mouthwash for mouth, gum, sore throat, gingivitis, dental and oral infections. It is also helpful in numerous women related problems. It also has abundant anti-microbial properties. This study aims at evaluating the physicochemical profile of Acacia catechu bark extract in order to make optimum use of the extract for therapeutic purposes.

Materials and Method: The plant material of Acacia catechu was shade dried at a temperature range of 20° to 30° C for about 2 weeks. The dried sample was then powdered in a grinding mill. The obtained powder was used for physico chemical analysis and for extraction using solvents.

Results: Ash value was found to be 12.7%. Acid insoluble & soluble content of the plant material was found to 1.67 & 6.26 %. The percentage weight of loss on drying or moisture content was found to be 7.245%. Extractive values found, are tabulated for different solvent systems. Ethanol 95 % showed 2.436 %.

Conclusion: Acacia catechu was characterized on the basis of the physicochemical parameters. The present work will, thus, provide helpful information on the quality of these herbal materials to ensure genuineness, safety and efficacy prior incorporation in pharmaceutical formulations.

Keywords

Acacia catechu, Solubility, Applications.

Full Text

     

Nivedhaa Chezhian ¹, Lakshmi Thangavelu ², S. Rajeshkumar ², Deepa Gurunathan ³, R. V. Geetha ⁴, Anitha Roy ²

Affiliations
1 Undergraduate Student, Department of Pharmacology, Saveetha Dental College, SIMATS, Saveetha University Chennai, Tamilnadu, IN
2 Associate Professor, Department of Pharmacology, Saveetha Dental College, SIMATS, Saveetha University Chennai, Tamilnadu, IN
3 Professor, Department of Pedodontics & Preventive Dentistry, Saveetha Dental College, SIMATS, Saveetha University Chennai, Tamilnadu, IN
4 Associate Professor, Department of Microbiology, Saveetha Dental College, SIMATS, Saveetha University Chennai, Tamilnadu, IN

Abstract

Aim: The aim is to study the interaction of Indole alkaloids against 2 oral carcinoma drug target by insilico docking using iGemdock tool.

Background: In this generation, technology has become so advanced that we are able to now achieve what was believed 20 years ago to be impossible. One such advancement is the in silico interactions. It is a virtual screening which enables us to bind two compounds and check the affinity of the binding. This helps us to first screen the activity of the two compounds before money, time and energy is spent in manually performing the activity and then arriving at a failure. We will be able to concentrate on the compounds which show us positive results in the in silico interactions, thus helping us in conserving time, expenditure and energy. Materials &

Method: The Oral carcinoma drug targets were identified by literature search and its 3D structure was downloaded from RCSB PDB (Protein Data Bank), which is a crystallographic database for the three-dimensional structural data of large biological molecules.

Results: From the above analysis it shows that ajmalicine shows good interaction with both the receptors also shows best fitness energy.

Keywords

Indole Alkaloids, Oral Carcinoma, Drug Target, Insilico Docking, Medication.

Full Text

     

Gayathri Karthikeyan ¹, T. Lakshmi ², S. Rajeshkumar ², Anitha Roy ², Deepa Gurunadhan ³, R. V. Geetha ⁴, R. Pradeep Kumar ⁵

Affiliations
1 Undergraduate Student, Department of Pharmacology, Saveetha Dental College, SIMATS, Saveetha University Chennai, Tamilnadu, IN
2 Associate Professor, Department of Pharmacology, Saveetha Dental College, SIMATS, Saveetha University Chennai, Tamilnadu, IN
3 Professor, Department of Pedodontics & Preventive Dentistry, Saveetha Dental College, SIMATS, Saveetha University Chennai, Tamilnadu, IN
4 Associate Professor, Department of Microbiology, Saveetha Dental College, SIMATS, Saveetha University Chennai, Tamilnadu,, IN
5 Professor, Department of Public Health Dentistry, Saveetha Dental College, SIMATS, Saveetha University Chennai, Tamilnadu, IN

Abstract

Introduction: Ficus racemosa is widely used in ayurvedic medicine in India, mostly as fruits and bark decoction to treat uncontrolled diabetes, the objective of this study is to study the uptake of glucose in L6 myotubes by Ficus racemosa.

Background: Diabetes is a common metabolic disease characterized by abnormally high plasma glucose levels, leasing to major complications, such as diabetic neuropathy, retinopathy and cardiovascular disease. Presently available oral hypoglycaemic agents exhibit several side effects. Therefore, there is a need for more effective oral antihyperglycemic agent, particularly those that normalize both insulin and glucose levels.

Method: Cell culture: L6, a mono layer myoblast culture (obtained from NCCS, Pune-Passageno-19) was cultured in the DMEM. In vitro glucose uptake activity: Glucose uptake assay was followed by the methodology of (Gupta et al).

Result: It was observed from the results that Ficus racemosa extract at different concentrations exhibited substantial degree of glucose uptake in skeletal muscle cells, which was compared with that of Standard Metformin. A maximum glucose uptake of 53% was observed for ficus 30mg/ml, whereas metformin exhibited 61% of glucose uptake. The IC50 of ficus extract and metformin was found to be 2.57mg/ml and 1.79mg/ml respectively.

Conclusion: From the study that was conducted above it can be concluded that Ficus racemosa had a better glucose uptake compared to the with that of Standard Metformin used by diabetic patients.

Keywords

Ficus racemose, Glucose, l6 Motube, Uptake, Myoblast.

Full Text

     

T. Nandhini ¹, T. Lakshmi ², S. Rajeshkumar ², Anitha Roy ², R. V. Geetha ³

Affiliations
1 Undergraduate Student, Department of Pharmacology, Saveetha Dental College, SIMATS, Saveetha University Chennai, Tamilnadu, IN
2 Associate Professor, Department of Pharmacology, Saveetha Dental College, SIMATS, Saveetha University Chennai, Tamilnadu, IN
3 Associate Professor, Department of Microbiology, Saveetha Dental College, SIMATS, Saveetha University Chennai, Tamilnadu, IN

Abstract

To investigate seed germination assay of Hemidesmus indicus ethanolic ischolar_main extract by an invitro study.It is a slender, laticiferous, twining, sometimes prostrate or semi-erect shrub. Roots are woody and aromatic. The stem is numerous, slender, terete, thickened at the nodes. The leaves are opposite, short-petioled, very variable, elliptic-oblong to linear- lanceolate. The flowers are greenish outside, purplish inside, crowded in sub-sessile axillary cyme. Seed germination study is an novel cost effective method in tissue culture techniques.

Keywords

Seed Germination, Hemidismus indicus, Ethanolic Root, Novel Technique.

Full Text

     

T. Sai Sandhya ¹, T. Lakshmi ², S. Rajeshkumar ², Anitha Roy ², Deepa Gurunathan ³, R. V. Geetha ⁴, R. Pradeep Kumar ⁵

Affiliations
1 Undergraduate Student, Department of Pharmacology, Saveetha Dental College, SIMATS, Saveetha University, Chennai, Tamilnadu, IN
2 Associate Professor, Department of Pharmacology, Saveetha Dental College, SIMATS, Saveetha University, Chennai, Tamilnadu, IN
3 Professor, Department of Pedodontics & Preventive Dentistry, Saveetha Dental College, SIMATS, Saveetha University, Chennai, Tamilnadu, IN
4 Associate Professor, Department of Microbiology, Saveetha Dental College, SIMATS, Saveetha University, Chennai, Tamilnadu, IN
5 Professor, Department of Public Health Dentistry, Saveetha Dental College, SIMATS, Saveetha University, Chennai, Tamilnadu, IN

Abstract

Introduction: Drug abuse is an extreme desire to obtain and use increasing amounts of one or more substances. Drug abuse indicates the following risk factors for developing drug abuse problems include poor relationships with parents, inadequate supervision over adolescent activities, poor achievement in schools and so on.

Materials & Method: An online survey comprising 17 questions was administered to the participants of age group 14-19.The results are statistically analysed.

Results and Discussion: From the survey conducted, it is analysed that 67%of the adolescents have attended many drug awareness programmes. 45% of them say that alcoholism and drug addiction are genetically inherited.

Conclusion: The abuse of alcohol and drugs has resulted in significant morbidity and mortality among adolescents worldwide.School-based health centers should have the capacity to counsel students who are in need of such treatment plans and connect students to available community resources.

Keywords

Drug Abuse, Poor Relationship, Marijuana, Health Centre, Community.

Full Text

     

S. Tanish Ahamad ¹, T. Lakshmi ², S. Rajeshkumar ², Anitha Roy ², Deepa Gurunadhan ³, R. V. Geetha ⁴

Affiliations
1 Undergraduate Student, Department of Pharmacology, Saveetha Dental College, SIMATS, Saveetha University, Chennai, Tamilnadu, IN
2 Associate Professor, Department of Pharmacology, Saveetha Dental College, SIMATS, Saveetha University, Chennai, Tamilnadu, IN
3 Professor, Department of Pedodontics & Preventive Dentistry, Saveetha Dental College, SIMATS, Saveetha University, Chennai, Tamilnadu, IN
4 Associate Professor,Department of Microbiology, Saveetha Dental College, SIMATS, Saveetha University Chennai, Tamilnadu, IN

Abstract

Aim: To evaluate Anti-Microbial Activity of taxifolin isolated from Acacia catechu leaf extract against Streptococcus mutans and Lactobacillus acidophilus.

Objectives: The study is to determine the antimicrobial activity of taxifolin isolated Acacia catechu leaf extract against Streptococcus mutans and Lactobacillus acidophilus.

Background: An anti microbial is a agent that kills or inhibits the growth of micro organism such as bacteria and fungi. Acacia catechu also commonly called Mimosa catechu, is a deciduous, thorny tree which grows up to 15 m (50 ft) in height. Acacia catechu traditionally used for curing many diseases and commonly for mother and child healthcare. Taxifolin is the main constituent of Acacia catechu which possesses antifungal, antiviral, antibacterial, anti-inflammatory and anti-oxidant activity.

Reason: This study is to evaluate the anti microbial activity of Acacia catechu against micro organisms such as Streptococcus mutans and Lactobacillus acidophilus. This may help in development of health products without artificial chemical agent.

Keywords

Antimicrobial, Herbal, Antibacterial, Acacia, S. mutans, L. acidophilus.

Full Text

     

Deepak Nallaswamy ¹, R. V. Geetha ², M. Subha ³

Affiliations
1 Professor, Department of Prosthodontics, Saveetha Dental College, Chennai, IN
2 Associate Professor, Department of Microbiology, Saveetha Dental College, Chennai, IN
3 Associate Professor, Department of Oral Medicine & Radiology, Saveetha Dental College, Chennai, IN

Abstract

Faculty development programme is a protocol followed by every institution for the betterment of the faculty. However, it’s not been standardised. This can be achieved only by assessing the faculty performance in a 360 degree way..Performance evaluation of faculty members is a challenge for the management. Any growing institution incorporates new innovations that becomes a task for the faculty. Hence, it is essential to have a standard and integrated appraisal system. It identifies strengths and weaknesses of teachers on all aspects, such as academic responsibilities, research profile, student evaluation, publications, acquiring research grants etc. Continuous Annual Faculty Evaluation was introduced to develop an inclusive and dynamic system of evaluation addressing all the activities and responsibilities of faculty members. After the introduction of CAFÉ system, the overall performance of the faculties showed a significant increase. This article describes in detail the performance of the faculty in all aspects after introducing CAFÉ.

Keywords

Faculty Performance, CAFE, Evaluation.

Full Text